پاورپوینت در مورد ریکتزیا (pptx) 73 اسلاید
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In the name of God
Rickettsia
Rickettsiosis and Ehrlichioses
R.fastidious bacterial ,
obligate ,
intracellular
Small, pleomorphic coccobacilli
Multiply by binary fission
Contain DNA & RNA
Synthetic & energy
Typhus & spotted fever contain endotoxins
Human infection
arthropods bite or
contamination with its feces
In Q fever inhalation , ingestion
Dr. Howard Taylor Rickett dead by typhus
Culture only in cellular culture
Incubation period 1 – 3 weeks
in spontaneous recovery , improvement begins
13- 16 days after
onset with
rapid drop of fever
Current medical diag. & treatment 2001 page 1341
Pathologic characteristicsRickettsia
Except Q fever
is vasculities
Proliferation of organism
in endothelial lining of small arteries , veins , capillaries
Pathogenesis
Rickettsia grow principally in endothelial cells of small vessels producing vacuities, cell necrosis , thrombosis of vessels .
Skin rashes , organ dysfunction
Except Q fever
( reticuloendithelial )
Ehrlichiosis ( hemathologic cell )
Clinical manifestationRickettsia
During appropriate season
( spring , summer )
Triad
fever , headache , rash
and myalgia ,nausea ,vomiting
Differential diag. Of Rickettsia
In primary lesion : chancre ,
anthrax
Fever phase :
A ) inf. Viral ,bact. ( typhoid , brucella Protozoa ( malaria … )
B ) Non inf. Lymphoprolyferative , ..
In pt. with rash : Next slide