پاورپوینت در مورد ریکتزیا (pptx) 73 اسلاید
                                    
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                                    In the name of God 
Rickettsia
Rickettsiosis and Ehrlichioses
R.fastidious bacterial ,
 obligate ,
 intracellular
Small, pleomorphic coccobacilli
Multiply by binary fission
Contain DNA & RNA
Synthetic & energy
Typhus & spotted fever contain endotoxins
Human infection 
 arthropods bite or
 contamination with its feces
In Q fever inhalation , ingestion
Dr. Howard Taylor Rickett dead by typhus
Culture only in cellular culture
Incubation period 1 – 3 weeks
 in spontaneous recovery , improvement begins
 13- 16 days after
 onset with
 rapid drop of fever
Current medical diag. & treatment 2001 page 1341
Pathologic characteristicsRickettsia
Except Q fever 
                is vasculities
Proliferation of organism 
       in endothelial lining of small arteries , veins , capillaries
Pathogenesis 
Rickettsia grow principally in endothelial cells of small vessels producing vacuities, cell necrosis , thrombosis of vessels .
 Skin rashes , organ dysfunction
Except Q fever  
( reticuloendithelial ) 
 Ehrlichiosis ( hemathologic cell )
Clinical manifestationRickettsia
During appropriate season
                        ( spring , summer )
Triad  
          fever , headache ,  rash  
and myalgia ,nausea ,vomiting
Differential diag. Of  Rickettsia
In primary lesion : chancre ,  
                                                     anthrax 
Fever phase :
    A ) inf. Viral ,bact. ( typhoid , brucella      Protozoa ( malaria … )
    B ) Non inf. Lymphoprolyferative , ..
In pt. with rash : Next slide